January 5, 2024Anesthesiology

Monitoring Argatroban Anticoagulation in the Critically Ill: All Tests Are Not Created Equal

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Structured PICO

Population

Critically ill patients treated with argatroban

Intervention

Coagulation assays (activated partial thromboplastin time [PTT], diluted thrombin time [TT], and point-of-care whole blood viscoelastic ecarin clotting time)

Comparator

Liquid chromatography with tandem mass spectrometry

Outcome

Correlation of coagulation assays to argatroban plasma concentrationssurrogate

Discussion

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Implication

In critically ill patients, standard coagulation assays like aPTT and ecarin clotting time show only modest correlation with true argatroban plasma concentrations measured by mass spectrometry.

Cite This Study

Erdoes et al. (2024) studied this question.

synapsesocial.com/papers/6a87336ec27ad527967ce378 https://doi.org/10.1097/aln.0000000000004814

Topics

Anticoagulation in AF

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Implication

In critically ill patients, standard coagulation assays like aPTT and ecarin clotting time show only modest correlation with true argatroban plasma concentrations measured by mass spectrometry.

Monitoring Argatroban Anticoagulation in the Critically Ill: All Tests Are Not Created Equal

Structured PICO

Discussion

Implication

Cite This Study

Topics

Monitoring Argatroban Anticoagulation in the Critically Ill: All Tests Are Not Created Equal

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider