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August 27, 2010American Journal Of PathologyOpen Access

Trophoblast- and Vascular Smooth Muscle Cell-Derived MMP-12 Mediates Elastolysis during Uterine Spiral Artery Remodeling

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Population

Primary first-trimester cytotrophoblasts derived from the placenta, cultured human aortic smooth muscle…

Comparison

Specific inhibitor of MMP-12; perfusion with… vs Control

Design

Preclinical

Authors

LHLynda K. HarrisSSSamantha D. SmithRKRosemary J. Keogh

Discussion

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Overview

Supports MMP-12 as a target in spiral artery remodeling; leaves open translation to in vivo pregnancy models or clinical applications.

Structured PICO

P
Population
Primary first-trimester cytotrophoblasts (CTBs) derived from the placenta, cultured human aortic smooth muscle cells (HASMCs), and isolated spiral artery segments
I
Intervention
Specific inhibitor of MMP-12; perfusion with CTB-conditioned medium
C
Comparator
Control
O
Outcome
Elastolysis (elastase activity)surrogate

MMP-12 derived from trophoblasts and vascular smooth muscle cells plays a key role in mediating elastolysis during uterine spiral artery remodeling in pregnancy.

Cite This Study

Harris et al. (2010) studied this question.

synapsesocial.com/papers/6a873379ed1c9801b3cfa5bfhttps://doi.org/10.2353/ajpath.2010.100182
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hydrolysis of a Broad Spectrum of Extracellular Matrix Proteins by Human Macrophage Elastase1997 · 325 citations
  2. 2Uterine Spiral Artery Remodeling Involves Endothelial Apoptosis Induced by Extravillous Trophoblasts Through Fas/FasL Interactions2004 · 185 citations
  3. 3Development of Selective Inhibitors and Substrate of Matrix Metalloproteinase-122006 · 151 citations
  4. 4Signaling Pathways Transduced through the Elastin Receptor Facilitate Proliferation of Arterial Smooth Muscle Cells2002 · 247 citations