Why the study?
Does flumazenil before ECT facilitate the simultaneous use of lorazepam and ECT in a patient with co-occurring catatonia and obsessive-compulsive disorder?
Does flumazenil before ECT facilitate the simultaneous use of lorazepam and ECT in a patient with co-occurring catatonia and obsessive-compulsive disorder?
Flumazenil can be used as a clinical tool before ECT to facilitate the simultaneous use of benzodiazepines and ECT in treatment-resistant cases.
May enable flumazenil-assisted ECT with lorazepam in catatonia-OCD; hypothesis-generating pending controlled trials.
Catatonia, associated with a variety of medical and psychiatric conditions such as mood disorders and schizophrenia, is frequently treated with either benzodiazepines or with electroconvulsive therapy (ECT) in treatment-resistant cases. Simultaneous treatment with both is usually avoided. Here, we report a case of the use of the benzodiazepine antagonist flumazenil before ECT to facilitate the simultaneous use of lorazepam and ECT for the treatment of co-occurring catatonia and obsessive-compulsive disorder. Both catatonia and obsessive-compulsive disorder symptoms improved in the patient. Physicians should be aware of flumazenil as a clinical tool for use in treatment-resistant cases.
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Makhinson et al. (2012) studied this question.
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