Describes a novel surgical technique in a puppy model to produce significant left ventricular hypertrophy via subcoronary valvular aortic stenosis.
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Advances preclinical LV hypertrophy models in puppies; leaves open translation to human aortic stenosis research.
Although techniques for producing aortic valve stenosis proximal to the ostia of the coronary arteries have been described in experimental animals, only moderate left ventricular hypertrophy has been obtained. A technique for plicating the noncoronary sinus of Valsalva in puppies is presented that has enabled us to achieve levels of ventricular hypertrophy not previously reported with methods for subcoronary aortic stenosis.
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Sink et al. (1980) studied this question.
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