Why the study?
Do specific reversal agents for NOACs improve the management of major bleeding and emergency surgical procedures in patients taking NOACs?
Do specific reversal agents for NOACs improve the management of major bleeding and emergency surgical procedures in patients taking NOACs?
The development of specific reversal agents for NOACs addresses a critical unmet need for managing severe bleeding and emergency surgeries, which may broaden the use of NOACs.
May increase clinician confidence in NOAC use amid bleeding risks; extends Level 1 evidence for targeted reversal strategies.
OBJECTIVE: The objective of this review is to provide an overview on the current development of the specific reversal agents for Non-vitamin K Oral Anticoagulants (NOACs). METHODS: We conducted a systematic literature search strategy to identify potential studies on Medline, Embase, and the Cochrane register. CONCLUSIONS: These new reversal agents for NOACs, will help address the unmet need for the management of major or life threatening bleeds, and the management of emergency surgical procedures in patients taking NOACs. It will increase confidence in the use of NOACs; thereby extending treatment to a wider range of patients.
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Dalal et al. (2016) studied this question.
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