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Myofilament calcium sensitivity should not yet change practice; leaves open its targeting in hypoxia and cardiotonic drug development.
In the heart, contractility may be varied over a wide range. It is determined mainly by the myoplasmic free calcium ion concentration. However, alteration of the responsiveness of the myofilaments to calcium may also be important in regulating cardiac contractility, in particular following changes in sarcomere length, or in hypoxia, or after interventions with certain novel cardiotonic drugs.
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J. C. Rüegg (1987) studied this question.
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