What question did this study set out to answer?

To investigate whether the long non-coding RNA HOXA11-AS promotes gastric cancer cell migration and invasion by regulating the miR-124-3p/ITGB3 pathway.

October 29, 2021Cancer Cell InternationalOpen Access

The long non-coding RNA HOXA11-AS activates ITGB3 expression to promote the migration and invasion of gastric cancer by sponging miR-124-3p

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Authors

LYLiting YouSichuan University QWQian WuUniversity of Connecticut ZXZhaodan XinSichuan University

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Implication

Preclinical study demonstrates that lncRNA HOXA11-AS drives cell invasion and migration through the miR-124-3p/ITGB3 axis in gastric cancer, indicating a potential therapeutic target.

Key Points

To investigate whether the long non-coding RNA HOXA11-AS promotes gastric cancer cell migration and invasion by regulating the miR-124-3p/ITGB3 pathway.
Examined HOXA11-AS, miR-124-3p, and ITGB3 expression in gastric cancer tissues and cell lines using RT-PCR and Western blotting.
Verified direct binding between HOXA11-AS and miR-124-3p using dual-luciferase reporter assays.
Conducted gain- and loss-of-function experiments to assess cell proliferation, migration, and invasion in vitro, followed by in vivo validation in mouse models.
HOXA11-AS is upregulated in gastric cancer tissues and directly binds miR-124-3p, acting as a competitive molecular sponge.
HOXA11-AS overexpression increases ITGB3 expression, markedly enhancing gastric cancer cell proliferation, migration, and invasion in vitro.
In vivo mouse assays confirmed that HOXA11-AS drives tumor cell migration and invasion through miR-124-3p downregulation and ITGB3 upregulation.

Cite This Study

You et al. (2021) studied this question.

synapsesocial.com/papers/6a8799fee6e02bcb4e7d6368 https://doi.org/10.1186/s12935-021-02255-6

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Implication

Preclinical study demonstrates that lncRNA HOXA11-AS drives cell invasion and migration through the miR-124-3p/ITGB3 axis in gastric cancer, indicating a potential therapeutic target.

The long non-coding RNA HOXA11-AS activates ITGB3 expression to promote the migration and invasion of gastric cancer by sponging miR-124-3p

Discussion

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Implication

Key Points

Cite This Study

The long non-coding RNA HOXA11-AS activates ITGB3 expression to promote the migration and invasion of gastric cancer by sponging miR-124-3p

Discussion

Member takes

Implication

Key Points

Cite This Study

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