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CarcinogenesisBLADDER carcinoma is believed to occur in humans after exposure to certain aromatic amines and is associated with bilharzial infestation in Egypt. It also occurs in domestic animals, notably Turkish cows that eat bracken fern, and may be produced in many laboratory animals with a variety of compounds.Rehn, in 1895,1 was the first to report on bladder cancers in man that may have been caused by a carcinogen. These carcinomas, termed "anilin cancers," were found in men who worked with dye stuffs, but it was not appreciated that the causative agent was probably an aromatic amine until nearly . . .
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George R. Prout (1972) studied this question.
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