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March 28, 2007European Heart Journal

Myocardial production of chromogranin A in human heart: a new regulatory peptide of cardiac function

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Population

40 patients with dilated cardiomyopathy, 20 patients with hypertrophic cardiomyopathy, and controls. Also…

Design

Cross-sectional

Authors

MPMaurizio PieroniACAngelo CortiBTBruno Tota

Discussion

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Overview

CgA may mark cardiomyopathy severity; hypothesis-generating for its neuroendocrine role in heart failure.

Structured PICO

P
Population
40 patients with dilated cardiomyopathy (DCM), 20 patients with hypertrophic cardiomyopathy (HCM), and controls. Also included isolated perfused rat hearts for functional assessment.
C
Comparator
Controls (for human samples)
O
Outcome
Myocardial production of chromogranin A (CgA), its correlation with left ventricular end-diastolic pressure and BNP levels, and its functional effects on isolated rat heartssurrogate

Chromogranin A is produced by the human myocardium, is elevated in cardiomyopathy, correlates with disease severity, and exerts negative inotropic effects, suggesting a role in the neuroendocrine regulation of heart failure.

Cite This Study

Pieroni et al. (2007) studied this question.

synapsesocial.com/papers/6a879f81ca6eee08f4f2ff48https://doi.org/10.1093/eurheartj/ehm022
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chromogranin A in heart failure. A novel neurohumoral factor and a predictor for mortality2002 · 206 citations
  2. 2Radioimmunoassay of Chromogranin a in Plasma as a Measure of Exocytotic Sympathoadrenal Activity in Normal Subjects and Patients with Pheochromocytoma1984 · 228 citations
  3. 3Chromogranin A protects vessels against tumor necrosis factor α‐induced vascular leakage2004 · 103 citations
  4. 4Rapid radioimmunoassay of circulating chromogranin A: in vitro stability, exploration of the neuroendocrine character of neoplasia, and assessment of the effects of organ failure.1989 · 172 citations
  5. 5Chromogranin A Fragments Modulate Cell Adhesion1997 · 77 citations