Population
Recombinant provirus generated during in vitro passage
Design
Preclinical
Authors
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ADAR edits retroviral RNA during in vitro recombination; leaves open in vivo occurrence and impact on viral evolution.
The study demonstrates that double-stranded RNA adenosine deaminase can modify retroviral RNA, leading to adenosine-to-guanosine hypermutation.
Hajjar et al. (1995) studied this question.
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