July 12, 2010PLoS ONEOpen Access

Hypertrophic Stimulation Increases β-actin Dynamics in Adult Feline Cardiomyocytes

View Full Paper

Ask AI

Bookmark

Population

Feline right ventricular pressure overload (RVPO) model and isolated adult feline cardiomyocytes

Comparison

Hypertrophic stimulation, adenoviral expression… vs Normal myocardium and unstimulated isolated…

Design

Preclinical

Authors

SBSundaravadivel BalasubramanianMedical University of South Carolina SMSanthosh K. ManiSohar University HKHarinath KasiganesanUniversity of Charleston

Discussion

Member takes

Implication

Beta-actin may modulate contractility in hypertrophy; hypothesis-generating for cytoskeletal targets pending human studies.

Structured PICO

Population

Feline right ventricular pressure overload (RVPO) model and isolated adult feline cardiomyocytes

Intervention

Hypertrophic stimulation (in vivo RVPO, in vitro endothelin or insulin), adenoviral expression of GFP-tagged beta-actin, and immunoneutralization of beta-actin

Comparator

Normal myocardium and unstimulated isolated cardiomyocytes

Outcome

Level, distribution, and dynamics of beta-actin, and cardiomyocyte contractilitysurrogate

Beta-actin is present and highly dynamic in adult cardiomyocytes, playing a significant role in cytoskeletal rearrangement and contractile function during hypertrophic stimulation.

Cite This Study

Balasubramanian et al. (2010) studied this question.

synapsesocial.com/papers/6a87a3576239aa4041f2fea7 https://doi.org/10.1371/journal.pone.0011470

View Full Paper

Ask AI

Bookmark

Hypertrophic Stimulation Increases β-actin Dynamics in Adult Feline Cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hypertrophic Stimulation Increases β-actin Dynamics in Adult Feline Cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider