Vasoactive substances such as ATP and histamine induce hyperpolarization in guinea-pig endocardial endothelial cells via Ca2+-dependent K+ channels, similar to vascular endothelial cells.
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Endocardial endothelial hyperpolarization parallels vascular responses in guinea pigs; extends mechanisms to cardiac endothelium but leaves open human relevance.
Manabe et al. (1995) studied this question.
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