PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 15, 2020Circulation Research39 citationsOpen Access

Transcriptional Patterning of the Ventricular Cardiac Conduction System

View Full Paper
Ask AI
Bookmark
Share

Why the study?

null

Population

Mouse models

Comparison

Adult VCS-specific removal of Tbx5 or… vs null

Design

Preclinical

Authors

OBOzanna Burnicka-TurekMBMichael BromanJSJeffrey D. Steimle

Discussion

Loading...

Member takes

Overview

Tbx5/Tbx3 balance maintains fast VCS conduction over nodal ground state; leaves open arrhythmia mechanisms and therapeutic targets in patients.

Structured PICO

null

P
Population
Mouse models
I
Intervention
Adult VCS-specific removal of Tbx5 or overexpression of Tbx3
C
Comparator
null
O
Outcome
Molecular and functional output of VCS myocytes (gene expression profiling, action potential characteristics, and rhythm consequences)surrogate

The balance between Tbx5 and Tbx3 determines the fast conduction phenotype of the ventricular conduction system, and its disruption leads to nodal-like physiology and lethal ventricular arrhythmias.

Cite This Study

Burnicka-Turek et al. (2020) studied this question.

synapsesocial.com/papers/6a87a6d779b981d85caca455https://doi.org/10.1161/circresaha.118.314460
View Full Paper
Ask AI
Bookmark
Share