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May 1, 1992Journal of Trauma and Acute Care Surgery

Coagulopathy and Catecholamines in Severe Head Injury

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Authors

TKThomas KearneyRutgers, The State University of New JerseyLBLaverne BenttCedars-Sinai Medical CenterMGMarshall L. GrodeCedars-Sinai Medical Center

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Implication

Prospective study reveals marked coagulopathy linked to mortality in severe head trauma patients, indicating a potential connection to systemic catecholamine surges.

Key Points

  • To evaluate the relationship between coagulopathy, catecholamine release, and survival outcomes in severe head trauma patients.
  • Prospective evaluation of 36 severe head trauma patients (Glasgow Coma Scale < 9; 10 penetrating, 26 blunt; 50% overall mortality) and a control group of 5 elective neurosurgery patients.
  • Analyzed coagulation profiles (platelet count, PT, PTT, fibrinogen, D-dimer, antithrombin III, protein C, protein S) and 24-hour urinary catecholamines (VMA, normetanephrine, metanephrine).
  • Head trauma survivors and nonsurvivors differed significantly in platelet count, prothrombin time, and fibrinogen activity, with no significant differences observed in other coagulation tests or urinary catecholamines.
  • Trauma patients exhibited significantly altered D-dimer, PT, PTT, protein C, and urinary normetanephrine levels compared to elective neurosurgery controls.

Cite This Study

Kearney et al. (1992) studied this question.

synapsesocial.com/papers/6a87a7e53c8582a8d3aca3cehttps://doi.org/10.1097/00005373-199205000-00012
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma catecholamines in severely injured patients: A prospective study on 45 patients with multiple injuries1975 · 132 citations
  2. 2Respective Contributions of Head and Extra-Head Injury Severities to the Occurrence of Early Coagulopathy Following Traumatic Brain Injury2026
  3. 3Cerebrospinal Fluid Catecholamine Levels as Predictors of Outcome in Subarachnoid Hemorrhage2012 · 36 citations
  4. 4The Relationship between Plasma Catecholamines and Severity of Injury in Man1984 · 89 citations
  5. 5Trauma-Induced Coagulopathy in Rat Models: Assessing Hemostatic Changes in Mild and Severe Traumatic Brain Injuries2026