What question did this study set out to answer?

To measure the penetration of systemic antibiotics into extravascular cerebral tissue and contrast these levels with cerebrospinal fluid concentrations in the absence of meningeal inflammation.

September 1, 1969Journal of neurosurgery

Antibiotic Penetration of the Brain

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Authors

PKPaul W. KramerUniversity of Fort Lauderdale RGR. S. GriffithClinical Research Solutions RCRobert L. CampbellBendigo Health

Discussion

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Implication

Clinical investigation examines antibiotic penetration into extravascular cerebral tissue in patients with uninflamed meninges, highlighting critical differences between brain and cerebrospinal...

Key Points

To measure the penetration of systemic antibiotics into extravascular cerebral tissue and contrast these levels with cerebrospinal fluid concentrations in the absence of meningeal inflammation.
Evaluated penetration characteristics across five antimicrobial agents: chloramphenicol, cephalothin, ampicillin, penicillin G, and cephaloridine.
Assessed drug concentration differentials between extravascular brain tissue and cerebrospinal fluid in patients without inflamed meninges.
Extravascular cerebral tissue penetration differs substantially from cerebrospinal fluid penetration, demonstrating that the blood-brain barrier and blood-cerebrospinal fluid barrier function distinctly.
Most systemic antibiotics demonstrate minimal recovery in cerebrospinal fluid following standard or elevated dosing, precluding cerebrospinal fluid concentrations from serving as a direct surrogate for brain tissue penetration.

Cite This Study

Kramer et al. (1969) studied this question.

synapsesocial.com/papers/6a87aa40efc8d8a4433e9643 https://doi.org/10.3171/jns.1969.31.3.0295

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September 1, 1969Journal of neurosurgery

Antibiotic Penetration of the Brain

View Full Paper

Ask AI

Bookmark

Authors

PKPaul W. KramerUniversity of Fort Lauderdale RGR. S. GriffithClinical Research Solutions RCRobert L. CampbellBendigo Health

Discussion

Member takes

Implication

Clinical investigation examines antibiotic penetration into extravascular cerebral tissue in patients with uninflamed meninges, highlighting critical differences between brain and cerebrospinal...

Key Points

To measure the penetration of systemic antibiotics into extravascular cerebral tissue and contrast these levels with cerebrospinal fluid concentrations in the absence of meningeal inflammation.
Evaluated penetration characteristics across five antimicrobial agents: chloramphenicol, cephalothin, ampicillin, penicillin G, and cephaloridine.
Assessed drug concentration differentials between extravascular brain tissue and cerebrospinal fluid in patients without inflamed meninges.
Extravascular cerebral tissue penetration differs substantially from cerebrospinal fluid penetration, demonstrating that the blood-brain barrier and blood-cerebrospinal fluid barrier function distinctly.
Most systemic antibiotics demonstrate minimal recovery in cerebrospinal fluid following standard or elevated dosing, precluding cerebrospinal fluid concentrations from serving as a direct surrogate for brain tissue penetration.

Cite This Study

Kramer et al. (1969) studied this question.

synapsesocial.com/papers/6a87aa40efc8d8a4433e9643 https://doi.org/10.3171/jns.1969.31.3.0295

View Full Paper

Ask AI

Bookmark