Seronegative and Seropositive Rheumatoid Arthritis

Article1 January 1964Seronegative and Seropositive Rheumatoid ArthritisClinical, Radiological, and Biochemical DifferencesJOHN H. BLAND, M.D., F.A.C.P., ESTELLE W. BROWN, B.S.JOHN H. BLAND, M.D., F.A.C.P.Search for more papers by this author, ESTELLE W. BROWN, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-1-88 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe majority of patients with rheumatoid arthritis diagnosed according to the American Rheumatism Association criteria (1) have positive latex or sensitized sheep cell agglutination tests (seropositive); the remainder have negative tests (seronegative). There are certain characteristics and correlations in respect to seropositivity (2, 3). Most patients with subcutaneous nodules are in the seropositive group. Vasculitis is more common in patients with strongly positive agglutination reactions; positive reactors more frequently exhibit positive lupus erythematosus cell preparations. Splenomegaly and lymphadenopathy are more frequent in seropositive patients. Latex or sheep cell agglutination tests, positive when rheumatoid arthritis is first diagnosed, usually remain positive....References1. ROPESBENNETTCOBBJACOXJESSAR MWGASRRA: 1958 Revision of diagnostic criteria for rheumatoid arthritis. Arthritis Rheum. 2: 16, 1959. CrossrefMedlineGoogle Scholar2. VAUGHAN JH: Serum responses in rheumatoid arthritis. Amer. J. Med. 26: 596, 1959. CrossrefMedlineGoogle Scholar3. VAUGHNBUTLER JHVP: Current status of the rheumatoid factor. Ann. Intern. Med. 56: 1, 1962. LinkGoogle Scholar4. MILGRAMWITEBSKY FE: Quoted as personal communication in Reference 2. Google Scholar5. SINGERPERALTYLYONSPLOTZ JMFMHDCM: Presence of serologically active macroglobulins in sera of some patients with active pulmonary tuberculosis. Arthritis Rheum. 4: 124, 1961. Google Scholar6. LAWRENCEBALL JSJ: Genetic studies in rheumatoid arthritis. Ann. Rheum. Dis. 17: 160, 1958. CrossrefMedlineGoogle Scholar7. DIXON AS: Rheumatoid arthritis with negative serological reaction. Ann. Rheum. Dis. 19: 209, 1960. CrossrefMedlineGoogle Scholar8. LONDONMUIRDENHEWITT MGKDVD: Serum cholesterol in rheumatic diseases. Brit. Med. J. In publication. Google Scholar9. KELLGRENBALL JHJ: Clinical significance of the rheumatoid serum factor. Brit. Med. J. 1: 523, 1959. CrossrefMedlineGoogle Scholar10. SINGERPLOTZ JMLM: Latex fixation test. 1. Application to serologic diagnosis of rheumatoid arthritis. Amer. J. Med. 21: 888, 1956. CrossrefMedlineGoogle Scholar11. LIDDLESEEGMILLERLASTER LMDL: The enzymatic spectrophotometric method for the determination of uric acid. J. Lab. Clin. Med. 54: 903, 1959. MedlineGoogle Scholar12. LEFFLER HH: Estimation of cholesterol in serum. Amer. J. Clin. Path. 31: 310, 1959. CrossrefMedlineGoogle Scholar13. GORNALLBARDAWILLDAVID AGCJMM: Determination of serum protein by means of biuret reaction. J. Biol. Chem. 177: 751, 1949. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Burlington, VermontFrom the Rheumatism Research Unit, Department of Medicine, University of Vermont, College of Medicine, Burlington, Vermont.This study was supported by United States Public Health Service training grant TI-AM-5087, National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland.Requests for reprints should be addressed to John H. Bland, M.D., Rheumatism Research Unit, University of Vermont, Medical Alumni Building, Burlington, Vermont. 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