Sex determination in man and other mammals can be accounted for in terms of three postulates. First, that unless specifically inhibited, the differentiation of the primary gonads goes in the male direction. Second, that the specific inhibiting factor is produced by a structural gene probably located on the X chromosome; this gene need be expressed only in cells of the urogenital ridge. Third, this gene is “switched off” (rendered inactive) by a repressor substance produced by a structural gene located on the Y chromosome.
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K Boczkowski (1971) studied this question.
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