Chromosome analysis of solid tumors. II.Twenty-six epithelial tumors

Of 26 epithelial cancers, most were clearly aneuploid. However, one breast cancer appeared classically diploid while two endometrial cancers were diploid or pseudo-diploid. Many cancers showed distinct karyotype variation from cell to cell in the same tumor. Occasional cells showed fragmentation of chromosomes or multiradial forms. A few tumors have shown increased numbers of small metacentrics with concomitant loss of small acrocentrics. A considerable number of tumor chromosome preparations showed diploid as well as aneuploid cells and the diploid cells tended to correlate with the degree of lymphocytic infiltrate seen in the histologic sections of the tumor.