Why the study?
Does measles virus fusion protein presented in an iscom induce immune responses and protect against fatal encephalopathy in monkeys and mice?
Population
Monkeys and mice
Design
Preclinical
Authors
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Supports iscom measles vaccine development in animals; leaves open translation to human protection.
Does measles virus fusion protein presented in an iscom induce immune responses and protect against fatal encephalopathy in monkeys and mice?
Measles virus proteins presented in immune-stimulating complexes are highly immunogenic and protective in animal models, suggesting potential for inactivated measles vaccine development.
Vries et al. (1988) studied this question.
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