January 1, 1987Viral Immunology

Inhibition of Measles Virus-Induced Cell—Cell Fusion with a Monoclonal Antibody Directed Against the Haemagglutinin

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Why the study?

Does a monoclonal antibody against the haemagglutinin of measles virus inhibit cell-cell fusion in measles virus-infected cells?

Population

Cultures of measles virus-infected cells

Design

Preclinical

Authors

PVPetra de VriesLeiden University RBRob van BinnendijkNational Institute for Public Health and the Environment PMP. van der MarelHealth Forecasting

Discussion

Member takes

Implication

Suggests anti-H mAb mechanism against measles spread in models; leaves open human therapeutic or vaccine implications.

Structured PICO

Does a monoclonal antibody against the haemagglutinin of measles virus inhibit cell-cell fusion in measles virus-infected cells?

Population

Cultures of measles virus-infected cells

Intervention

Neutralizing monoclonal antibody (C26-15) against the haemagglutinin (H protein) of measles virus, or polyclonal rabbit serum directed against Tween-ether inactivated measles virus

Outcome

Cell-cell fusion inhibitionsurrogate

Anti-H antibodies can inhibit measles virus-induced cell-cell fusion by down-regulating viral glycoproteins, suggesting an alternative mechanism for preventing virus spread and potentially explaining insufficient protection from inactivated vaccines.

Cite This Study

Vries et al. (1987) studied this question.

synapsesocial.com/papers/6a94dbc853e09118be7c3fa9 https://doi.org/10.1089/vim.1987.1.25

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Inhibition of Measles Virus-Induced Cell—Cell Fusion with a Monoclonal Antibody Directed Against the Haemagglutinin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of Measles Virus-Induced Cell—Cell Fusion with a Monoclonal Antibody Directed Against the Haemagglutinin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider