The Low Efficiency of Maternal-Neonatal Transmission of Hepatitis C Virus: How Certain Are We?

Editorials1 December 1992The Low Efficiency of Maternal-Neonatal Transmission of Hepatitis C Virus: How Certain Are We?Raymond S. Koff, MDRaymond S. Koff, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-11-967 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHepatitis C virus (HCV) is a hot topic. Because the literature is constantly expanding, keeping current with new research is no simple task for either the clinician or investigator. The "big bang" of HCV research is readily traced to the brilliant efforts and perseverance of Houghton and colleagues who, working collaboratively with Bradley, cloned the HCV genome (1). This remarkable achievement permitted a proliferation of specific assays to study HCV infection. The humoral immune response to HCV was assessed initially by radioimmunoassay, but the development of first-generation enzyme-linked immunosorbent assays (ELISAs) and recombinant immunoblot assays (RIBAs) and then second-generation assays...References1. ChooKuoWeinerOverbyBradleyHoughton QGALDM. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 1989;244:359-62. CrossrefMedlineGoogle Scholar2. ChaudharyMacLean RC. Evaluation of first- and second-generation RIBA kits for detection of antibody to hepatitis C virus. J Clin Microbiol. 1991;29:2329-30. CrossrefMedlineGoogle Scholar3. McHutchisonPersonGovindarajanValinluckGoreLee JJSBTS. Improved detection of hepatitis C virus antibodies in high-risk populations. Hepatology. 1992;15:19-25. CrossrefMedlineGoogle Scholar4. VallariJettAlterMimmsHolzmanShih DBHLRJ. Serological markers of posttransfusion hepatitis C viral infection. J Clin Microbiol. 1992;30:552-6. CrossrefMedlineGoogle Scholar5. 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Author, Article, and Disclosure InformationAffiliations: University of Massachusetts Medical Center MetroWest Medical Center Framingham, MA 01701 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLiver DiseasesHepatitis C: an epidemiological reviewContaining Hepatitis CBases décisionnelles d'un essai de prophylaxie de la transmission périnatale de l'hépatite C par immunoglobulines spécifiquesVertical transmission of hepatitis C Virus: An epidemiological study on 2,980 pregnant women in ItalyVertical Transmission of Hepatitis C Virus InfectionVirus infections in pregnancyEpidemiology and prevention of hepatitis type C in ItalyThe mammography and prostate-specific antigen controversiesTransmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulinMulti-organ donor transmission of hepatitis C virus to five solid organ transplant recipients and lack of transmission to corneal transplant recipientsViral hepatitisHeterosexual transmission of hepatitis C virus and the possible role of coexistent human immunodeficiency virus infection in the index case: A multicentre study of 423 pairingsPrevalence of antibodies against hepatitis B and C virus among pregnant women and female blood donors in SwedenHepatitis C virus infection from blood and blood productsTransmission of Hepatitis C Virus from Mothers to InfantsManagement of chronic hepatitis in special populations 1 December 1992Volume 117, Issue 11Page: 967-969KeywordsEnzyme linked immunosorbent assayHepatitis C virusHospital medicineHumoral immune responseRadioimmunoassays Issue Published: 1 December 1992 PDF downloadLoading ...