Why the study?
Does a combination of core, NS3, and c100 antigens improve the early detection of anti-HCV antibodies compared to c100 antigen alone in posttransfusion hepatitis patients?
Population
14 posttransfusion chronic non-A, non-B hepatitis patients
Comparison
Semiquantitative dot blot immunoassay using… vs Current screening tests using only the c100…
Design
Cohort
Follow-up
greater than 3 years
Authors
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May enable earlier posttransfusion HCV detection; leaves open whether multi-antigen assays improve screening outcomes.
Does a combination of core, NS3, and c100 antigens improve the early detection of anti-HCV antibodies compared to c100 antigen alone in posttransfusion hepatitis patients?
Using a combination of core, NS3, and c100 antigens significantly shortens the window period for detecting HCV antibodies following posttransfusion hepatitis compared to single-antigen assays.
Vallari et al. (1992) studied this question.
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