Why the study?
Does antipsychotic dose escalation increase the risk of Neuroleptic Malignant Syndrome in elderly patients with hyponatremia?
Does antipsychotic dose escalation increase the risk of Neuroleptic Malignant Syndrome in elderly patients with hyponatremia?
Hyponatremia may predispose elderly patients to neuroleptic malignant syndrome upon antipsychotic dose escalation.
May warrant caution with antipsychotic escalation in hyponatremic elderly; hypothesis-generating and requires prospective validation.
Neuroleptic malignant syndrome (NMS) is a rare, life-threatening idiosyncratic reaction secondary to antipsychotic medication. Hyponatremia frequently develops in elderly patients and also psychiatric patients and may associate with neuroleptic malignant syndrome. This case report presents a male patient developing NMS secondary to antipsychotic dose escalation on the basis of hyponatremia. [PBS 2016; 6(2.000): 71-3]
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Annagür et al. (2016) studied this question.
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