What question did this study set out to answer?

To construct an individualized immune microenvironment prognostic signature and identify key regulatory genes and signaling pathways in prostate cancer.

October 27, 2020Open Access

Development and Validation of an Immune Microenvironment Based Prognostic Signature and Signal Pathways in Prostate Cancer

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Authors

QZQi ZhaoHebei Medical University YCYingying ChengSun Yat-sen University YRYujie RenWenzhou Medical University

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Implication

Translational multi-cohort and experimental study reveals LTF inhibits progression in prostate cancer, highlighting targeted prognostic strategies.

Key Points

To construct an individualized immune microenvironment prognostic signature and identify key regulatory genes and signaling pathways in prostate cancer.
Analyzed genomic and clinical data from 591 prostate cancer samples across TCGA and GEO cohorts using CIBERSORT, ESTIMATE, and ssGSEA algorithms to evaluate immune cell infiltration and tumor mutational burden.
Identified microenvironment-related intersection genes using the ImmPort database and performed pan-cancer pathway analyses.
Validated the functional mechanisms of the core gene LTF using Western blot and cellular assays in prostate cancer cell lines.
Significant differences in M0, M2, and resting mast cells were identified between tumor and normal tissues, with lower plasma cell abundance correlating with lymph node metastasis.
Low expression of the core hub gene LTF was associated with immune deficiency, cancer progression, and activation of the JAK/STAT signaling pathway.
Overexpression of LTF suppressed tumor-derived GM-CSF secretion through JAK/STAT pathway inhibition, reducing prostate cancer cell proliferation and migration.

Cite This Study

Zhao et al. (2020) studied this question.

synapsesocial.com/papers/6a87ae657596ae0644e67f30 https://doi.org/10.21203/rs.3.rs-96227/v1

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Implication

Translational multi-cohort and experimental study reveals LTF inhibits progression in prostate cancer, highlighting targeted prognostic strategies.

Development and Validation of an Immune Microenvironment Based Prognostic Signature and Signal Pathways in Prostate Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Development and Validation of an Immune Microenvironment Based Prognostic Signature and Signal Pathways in Prostate Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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