Population
Cardiomyocytes from control and diabetic db/db mice, and transgenic db/db mice overexpressing hGLUT4
Comparison
Insulin stimulation vs Control cardiomyocytes or untreated db/db…
Design
Preclinical
Authors
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Selective post-Akt insulin resistance in diabetic cardiomyocytes; hypothesis-generating for human cardiac metabolism studies.
Insulin resistance in db/db cardiomyocytes manifests selectively as reduced insulin-stimulated deoxyglucose uptake, while Akt phosphorylation remains intact.
Carroll et al. (2005) studied this question.
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