What question did this study set out to answer?

To investigate arterial stiffness using brachial-ankle pulse wave velocity in individuals with vascular dementia compared with Alzheimer's disease and dementia-free controls.

August 15, 2003Journal of the American Geriatrics Society

Pulse Wave Velocity in Persons with Vascular Dementia

View Full Paper

Ask AI

Bookmark

Why the study?

Is brachial-ankle pulse wave velocity increased in patients with vascular dementia compared to those with Alzheimer's disease or without dementia?

Population

Individuals with vascular dementia (n=16), Alzheimer's disease (n=18), and without dementia (n=44).

Comparison

Measurement of brachial-ankle pulse wave velocity vs Comparison between vascular dementia…

Design

Cross-sectional

Authors

YMYutaka MizushimaNihon University HOHiromi Oobasawa SYSatoshi YoshidaShinshu University

Discussion

Member takes

Implication

baPWV was associated with vascular dementia; should not yet change practice and leaves open prospective validation.

Key Points

To investigate arterial stiffness using brachial-ankle pulse wave velocity in individuals with vascular dementia compared with Alzheimer's disease and dementia-free controls.
Measured brachial-ankle pulse wave velocity (baPWV) using a pulse wave velocity/ankle brachial index device in a baseline cohort without dementia (n=96) to establish demographic and blood pressure associations.
Compared baPWV measurements across three groups: vascular dementia (n=16; mean age 76.0±1.4 years), Alzheimer's disease (n=18; mean age 74.2±2.5 years), and controls without dementia (n=44; mean age 72.2±1.0 years).
The baPWV was significantly higher in individuals with vascular dementia (2,361±138) than in those with Alzheimer's disease (1,873±79) or controls without dementia (1,900±64; P < .01).
A significant correlation between baPWV and age was observed in the Alzheimer's disease group, but no correlation was observed in the vascular dementia group.
In dementia-free individuals, baPWV increased with advancing age (P < .001) and was significantly higher in hypertensive than normotensive participants (1,985±92 vs 1,644±41, P < .001).

Structured PICO

Is brachial-ankle pulse wave velocity increased in patients with vascular dementia compared to those with Alzheimer's disease or without dementia?

Population

Individuals with vascular dementia (n=16), Alzheimer's disease (n=18), and without dementia (n=44).

Intervention

Measurement of brachial-ankle pulse wave velocity (baPWV)

Comparator

Comparison between vascular dementia, Alzheimer's disease, and no dementia groups

Outcome

Brachial-ankle pulse wave velocity (baPWV)surrogate

Brachial-ankle pulse wave velocity is significantly elevated in patients with vascular dementia compared to those with Alzheimer's disease or no dementia, suggesting its potential utility as a screening tool for vascular dementia risk.

Limitations

preliminary study
small sample size

Cite This Study

Mizushima et al. (2003) studied this question.

synapsesocial.com/papers/6a87b66d3bdf89560ead281b https://doi.org/10.1046/j.1532-5415.2003.514208.x

View Full Paper

Ask AI

Bookmark

Pulse Wave Velocity in Persons with Vascular Dementia

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Pulse Wave Velocity in Persons with Vascular Dementia

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider