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December 1, 2020OncoTargets and TherapyOpen Access

Prognostic Value of Preoperative Albumin-to-Alkaline Phosphatase Ratio in Patients with Muscle-Invasive Bladder Cancer After Radical Cystectomy

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Why the study?

This study investigated the prognostic value of the preoperative albumin alkaline phosphatase ratio in patients with muscle-invasive bladder cancer after radical cystectomy.

Does preoperative AAPR predict survival outcomes in patients with muscle-invasive bladder cancer after radical cystectomy?

Population

174 patients with muscle-invasive bladder cancer after radical cystectomy and urinary diversion

Comparison

Preoperative albumin alkaline phosphatase ratio levels or tertiles

Design

Retrospective, single-center cohort study

Follow-up

Median 30 months

Authors

MZMing ZhaoQingdao UniversityMZMingxin ZhangAir Force Medical UniversityYWYonghua WangNorthwest University

Discussion

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Member takes

Overview

May support risk stratification after cystectomy; leaves open prospective validation before clinical adoption.

Structured PICO

Does preoperative AAPR predict survival outcomes in patients with muscle-invasive bladder cancer after radical cystectomy?

P
Population
174 patients with muscle-invasive bladder cancer who underwent radical cystectomy and urinary diversion
I
Intervention
Preoperative albumin-to-alkaline phosphatase ratio (AAPR) assessment
C
Comparator
Low vs high AAPR tertiles
O
Outcome
Overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS)hard clinical

Preoperative AAPR is a potentially valuable prognostic marker for survival in patients undergoing radical cystectomy for muscle-invasive bladder cancer.

Cite This Study

Zhao et al. (2020) studied this question.

synapsesocial.com/papers/6a87b67bf455bdf6826c8018https://doi.org/10.2147/ott.s285098
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Albumin-to-Alkaline Phosphatase Ratio: A Novel Prognostic Index for Hepatocellular Carcinoma2015 · 114 citations
  2. 2Assessment of Liver Function in Patients With Hepatocellular Carcinoma: A New Evidence-Based Approach—The ALBI Grade2014 · 2,853 citations
  3. 3The association of preoperative serum albumin level and <scp>A</scp> merican <scp>S</scp> ociety of <scp>A</scp> nesthesiologists ( <scp>ASA</scp> ) score on early complications and survival of patients undergoing radical cystectomy for urothelial bladder cancer2013 · 102 citations
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  5. 5NCCN Guidelines Insights: Bladder Cancer, Version 5.20182018 · 220 citations