Why the study?
Does radiotherapy increase the risk of secondary malignancy in long-term survivors of Ewing sarcoma?
Does radiotherapy increase the risk of secondary malignancy in long-term survivors of Ewing sarcoma?
Postoperative radiotherapy should be avoided in Ewing sarcoma when surgery with adequate margins is feasible due to an increased risk of secondary malignancies.
Radiotherapy may raise secondary malignancy risk in Ewing sarcoma survivors; leaves open whether avoidance improves long-term outcomes.
The relative risk of second tumors in patients with Ewing sarcoma is controversial, and little is known about their treatment and outcome. The purpose of the current study was to define the incidence and features of second tumors among 597 long-term survivors of nonmetastatic Ewing sarcoma treated with adjuvant and neoadjuvant chemotherapy, radiotherapy, and/or surgery. The authors found that the risk of secondary malignancy after adjuvant or neoadjuvant treatment of Ewing sarcoma is higher than that after other childhood or adolescent cancers only after radiotherapy. Based on this, postoperative radiotherapy should be avoided when surgery with adequate margins is feasible.
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Bacci et al. (2005) studied this question.
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