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April 15, 1982Cancer

The treatment of localized Ewing's sarcoma: The experience at the istituto ortopedico rizzoli in 163 cases treated with and without adjuvant chemotherapy

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Why the study?

Does adjuvant chemotherapy plus local tumor control reduce mortality and metastasis in patients with localized Ewing's sarcoma?

Population

163 patients with localized Ewing's tumor

Comparison

Adjuvant chemotherapy for two years plus local… vs Radiotherapy, or surgery plus radiotherapy…

Design

Cohort

Follow-up

21-101 months (mean = 50 months)

Authors

GBGaetano BacciIstituto Ortopedico Gaetano PiniPPPiero PicciUniversité Paris-SudSGSteven GitelisRush University Medical Center

Discussion

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Implication

Supports consideration of adjuvant chemotherapy; leaves open need for randomized confirmation before practice change.

Structured PICO

Does adjuvant chemotherapy plus local tumor control reduce mortality and metastasis in patients with localized Ewing's sarcoma?

P
Population
163 patients with localized Ewing's tumor (80 treated with adjuvant chemotherapy plus local tumor control, 83 previously treated without chemotherapy)
I
Intervention
Adjuvant chemotherapy for two years plus local tumor control (amputation, resection plus radiotherapy, or radiotherapy alone)
C
Comparator
Radiotherapy, or surgery plus radiotherapy without chemotherapy
O
Outcome
Mortality rate and incidence of metastasishard clinical

Adjuvant chemotherapy combined with local tumor control significantly reduces mortality and metastasis in localized Ewing's sarcoma compared to local therapy alone.

Cite This Study

Bacci et al. (1982) studied this question.

synapsesocial.com/papers/6a97e4c8d08ffd74dfc634b8https://doi.org/10.1002/1097-0142(19820415)49:8<1561::aid-cncr2820490808>3.0.co;2-k
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adjuvant chemotherapy in the treatment of clinically localised Ewing's sarcoma1978 · 20 citations
  2. 2Management and results of localized Ewing's sarcoma1979 · 84 citations
  3. 3Localized ewing's sarcoma—treatment and results1974 · 98 citations
  4. 4Treatment of clinically localized Ewing's sarcoma with radiotherapy and combination chemotherapy1972 · 114 citations
  5. 5Altered pattern of metastasis following treatment of Ewing's sarcoma with radiotherapy and adjuvant chemotherapy1971 · 67 citations