Key result
Adjuvant chemotherapy plus radiotherapy or surgery is linked to markedly lower mortality and metastasis.
Why the study?
The impact of adjuvant chemotherapy combined with radiotherapy and/or operation on mortality, metastases, and local recurrence in clinically localised Ewing's sarcoma was unclear compared to previous treatments without chemotherapy.
Does adjuvant chemotherapy combined with radiotherapy and/or operation improve mortality and reduce metastases in patients with clinically localised Ewing's sarcoma?
Comparison
Radiotherapy and/or operation plus adjuvant chemotherapy vs radiotherapy alone or operation plus radiotherapy without chemotherapy
Design
Observational cohort study
Authors
Loading...
May support multimodal therapy in Ewing's sarcoma; leaves open confirmation in randomized trials.
Observational (n=37)
Does adjuvant chemotherapy combined with radiotherapy and/or operation improve mortality and reduce metastases in patients with clinically localised Ewing's sarcoma?
Adjuvant chemotherapy combined with radiotherapy and operative excision appears to reduce mortality and metastases in clinically localised Ewing's sarcoma.
Bacci et al. (1978) conducted an observational in Clinically localised Ewing's sarcoma (n=37). Adjuvant chemotherapy (vincristine, cyclophosphamide, adriamycin) vs. Historical series treated without chemotherapy was evaluated on Mortality rate and incidence of metastases. Adjuvant chemotherapy combined with radiotherapy and/or operation markedly lowered mortality and metastasis rates compared to historical controls without chemotherapy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: