Ewing's sarcoma.Case against surgery

Carl W. Boyer; Theodore J. Brickner; Ronald H. Perry

doi:10.1002/1097-0142(196710)20:10<1602::aid-cncr2820201006>3.0.co;2-h

October 1, 1967CancerOpen Access

Ewing's sarcoma.Case against surgery

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Why the study?

Does radiation therapy improve outcomes compared to surgery in patients with Ewing's sarcoma?

Key Points

To evaluate the necessity of radical surgical intervention compared to radiation therapy for local control and palliation in Ewing sarcoma.
Retrospective review of clinical outcomes from 30 cases of Ewing sarcoma treated since 1949.
Comparison of radical surgical resection outcomes against supervoltage radiation therapy regimens.
Radical surgical resection, including limb amputation, demonstrated no therapeutic advantage in managing primary lesions.
Radiation therapy consistently controlled primary tumor lesions and provided the most effective palliation for metastatic spread.
Supervoltage radiation was identified as the optimal primary treatment modality for all presented cases.

Structured PICO

Does radiation therapy improve outcomes compared to surgery in patients with Ewing's sarcoma?

P

Population

30 cases of Ewing's sarcoma treated at Walter Reed General Hospital since 1949

I

Intervention

Radiation therapy (supervoltage radiation)

C

Comparator

Surgery (removal of limbs and other portions of the body)

O

Outcome

Control of the lesion and palliation of metastasis

Supervoltage radiation is the treatment of choice for Ewing's sarcoma, rendering radical surgery unnecessary.

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Implication

Should not yet change practice in Ewing sarcoma; leaves open the role of modern multimodal regimens versus historical radiation alone.

Abstract

Thirty cases of Ewing's sarcoma have been treated at Walter Reed General Hospital since 1949. A review of this experience and that of others has failed to reveal any valid reason for a heroic surgical attack. Removal of limbs and other portions of the body has become a needless surgical exercise. Radiation therapy regularly controls the lesion and is the most effective agent for palliation of metastasis. Supervoltage radiation is the treatment of choice in all cases.

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Cite This Study

Boyer et al. (1967) studied this question.

synapsesocial.com/papers/6a87b8eac0493623866c7d93 https://doi.org/10.1002/1097-0142(196710)20:10<1602::aid-cncr2820201006>3.0.co;2-h

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Ewing's sarcoma.Case against surgery

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Ewing's sarcoma.Case against surgery

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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