What question did this study set out to answer?

Identify the enterotoxin-antienterotoxin precipitate band using gel diffusion and assess serological cross-reactivity and neutralization among various staphylococcal strains.

September 1, 1959The Journal of Immunology

Staphylococcal Enterotoxin

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Authors

MBMerlin S. BergdollNorthwestern University MSMichael J. SurgallaRoswell Park Comprehensive Cancer Center GDG. M. DackMinistère de la Santé et de l'Hygiène Publique

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Implication

Experimental study demonstrates serological cross-reactivity across diverse staphylococcal enterotoxin strains, indicating antigenic variability among food poisoning isolates.

Key Points

Identify the enterotoxin-antienterotoxin precipitate band using gel diffusion and assess serological cross-reactivity and neutralization among various staphylococcal strains.
Generated a monovalent antiserum specific for enterotoxin isolated from Staphylococcus strain S-6.
Evaluated serological cross-reactivity with enterotoxins from 14 food-poisoning strains using gel diffusion and the Oudin technique.
Compared in vitro equivalence ratios derived from gel diffusion against in vivo equivalence ratios from oral monkey neutralization assays.
Potent enterotoxin from 13 food poisoning strains cross-reacted with the anti-S-6 monovalent serum, whereas enterotoxin from strain 196E showed no cross-reaction.
The equivalence ratio measured by the Oudin technique was 2- to 3-fold higher than the equivalence ratio determined through oral neutralization studies in monkeys.

Cite This Study

Bergdoll et al. (1959) studied this question.

synapsesocial.com/papers/6a87b99d1c150529da48ef17 https://doi.org/10.4049/jimmunol.83.3.334

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Implication

Experimental study demonstrates serological cross-reactivity across diverse staphylococcal enterotoxin strains, indicating antigenic variability among food poisoning isolates.

Staphylococcal Enterotoxin

Discussion

Member takes

Implication

Key Points

Cite This Study

Staphylococcal Enterotoxin

Discussion

Member takes

Implication

Key Points

Cite This Study

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