A mimic of monooxygenase enzymes: An artificial cytochrome P-450 with four cyclodextrins linked to a manganese/porphyrin complex can insert an oxygen atom into unactivated C−H bonds with catalytic turnovers (see picture). Hydroxylation of a doubly bound diester of androstane-3,17-diol at C-6 is possible; further oxidation of the triply bound triester of this product occurs at C-9.
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Jerry Yang (2000) studied this question.
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