Experimental study demonstrates palladium-catalyzed four-component carbonylation of aryl and alkyl halides in water, suggesting a greener route to synthesize diverse aromatic esters.
A convenient four-component reaction has been developed that allows for the direct transformation of aryl iodides with alkyl halides into the corresponding aromatic esters and diesters via palladium-catalyzed carbonylation with water as solvent. Various esters and diesters were isolated in moderate to good yields with broad functional group tolerance.
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Zhu et al. (2022) studied this question.
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