Recent advances in surface engineering and soft lithography provide tools to fabricate patterned surfaces and microfluidic devices with dimensions comparable to the sizes of single mammalian cells. These technologies enable the studies of individual cells on spatially well‐defined, patterned surfaces, and in contact with patterned liquid media. They provide information about cells impossible to obtain from traditional biochemical techniques.
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Jiang et al. (2003) studied this question.
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