Why the study?
Aortic stenosis with cardiac amyloidosis is common in the elderly, prompting an evaluation of outcomes following aortic valve intervention.
Does aortic valve intervention reduce all-cause mortality in patients with aortic stenosis and cardiac amyloidosis compared to patients with aortic stenosis alone?
Does aortic valve intervention reduce all-cause mortality in patients with aortic stenosis and cardiac amyloidosis compared to patients with aortic stenosis alone?
Answers are grounded in this paper and cite their sources.
Aortic valve intervention in patients with concurrent aortic stenosis and cardiac amyloidosis yields comparable mortality risks to those with aortic stenosis alone, suggesting the procedure is not futile and should not be withheld.
Aortic stenosis with cardiac amyloidosis (CA-AS) is common in the elderly. We provide an overview and a meta-analysis of outcomes after aortic valve (AV) intervention. The primary end point was all-cause mortality. Weighted pooled analysis showed a non-significant higher risk of death in CA-AS patients following surgical or transcatheter AV replacement. After transcatheter AV replacement, the risk of death in CA-AS patients was comparable to that associated with aortic stenosis alone (risk ratio: 1.23; 95% CI: 0.77–1.96; p = 0.39; I2 = 0%). An AV intervention is possibly not futile in CA-AS and should not be denied to patients with this condition.
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Campos et al. (2022) studied this question.
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