What question did this study set out to answer?

To determine whether dietary supplementation with Lorenzo's oil alters the fatty acid composition in postmortem brain and liver tissues of an adrenoleukodystrophy patient.

November 1, 1994Annals of Neurology

Very long chain fatty acids in X‐linked adrenoleukodystrophy brain after treatment with Lorenzo's oil

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Authors

APAlfred PoulosAustralian National University RGRobert A. GibsonSouth Australian Health and Medical Research Institute PSP. SharpSouth Australia Pathology

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Implication

Postmortem tissue analysis reveals Lorenzo's oil fails to alter brain fatty acids in adrenoleukodystrophy, suggesting limited therapeutic value.

Key Points

To determine whether dietary supplementation with Lorenzo's oil alters the fatty acid composition in postmortem brain and liver tissues of an adrenoleukodystrophy patient.
Analyzed postmortem brain and liver fatty acid profiles from a single patient with adrenoleukodystrophy treated with dietary Lorenzo's oil for 9 months.
Measured levels of saturated very long chain fatty acids (24:0 and 26:0), erucic acid (22:1), nervonic acid (24:1), polyunsaturated fatty acids, and markers of essential fatty acid deficiency.
Lorenzo's oil depressed saturated very long chain fatty acids (24:0 and 26:0) and increased erucic and nervonic acids in plasma and liver.
Plasma linoleic, eicosapentaenoic, and docosahexaenoic acids were reduced, while a marker for essential fatty acid deficiency (20:3 n-9) was markedly elevated in liver.
No corresponding changes in fatty acid levels occurred in brain tissue, indicating that minimal erucic acid crossed the blood-brain barrier.

Cite This Study

Poulos et al. (1994) studied this question.

synapsesocial.com/papers/6a87be5491c33485a1fe77df https://doi.org/10.1002/ana.410360509

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Implication

Postmortem tissue analysis reveals Lorenzo's oil fails to alter brain fatty acids in adrenoleukodystrophy, suggesting limited therapeutic value.

Very long chain fatty acids in X‐linked adrenoleukodystrophy brain after treatment with Lorenzo's oil

Discussion

Member takes

Implication

Key Points

Cite This Study

Very long chain fatty acids in X‐linked adrenoleukodystrophy brain after treatment with Lorenzo's oil

Discussion

Member takes

Implication

Key Points

Cite This Study

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