What question did this study set out to answer?

March 1, 1979Journal of Clinical MicrobiologyOpen Access

Measurement of immunoglobulin M (IgM), IgG, and IgA antibodies against Yersinia enterocolitica by enzyme-linked immunosorbent assay: persistence of serum antibodies during disease

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Authors

KGKaisa GranforsNational Institutes of Health

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Implication

Observational study reveals prolonged IgA antibody persistence in patients with Yersinia-associated arthritis, indicating an association with post-infectious complications.

Key Points

To develop an enzyme-linked immunosorbent assay (ELISA) for measuring IgM, IgG, and IgA antibodies against Yersinia enterocolitica and characterize their persistence during clinical disease.
Developed an ELISA using formalinized or heat-treated Yersinia enterocolitica coated on microcuvettes, utilizing class-specific rabbit antisera and alkaline phosphatase conjugates.
Tested 423 serum samples in comparison with standard tube agglutination testing, tracking antibody persistence longitudinally in six patients over 9 to 14 months.
IgM antibodies persisted for only 1 to 3 months after onset, indicating that IgM presence reflects a recently acquired infection.
IgA antibodies persisted throughout the 9- to 14-month follow-up in all 3 patients with reactive arthritis, whereas IgA antibodies cleared within 3 months in all 3 patients without arthritis.

Cite This Study

Kaisa Granfors (1979) studied this question.

synapsesocial.com/papers/6a87c15324ca9e5e6301574f https://doi.org/10.1128/jcm.9.3.336-341.1979

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Implication

Observational study reveals prolonged IgA antibody persistence in patients with Yersinia-associated arthritis, indicating an association with post-infectious complications.

Measurement of immunoglobulin M (IgM), IgG, and IgA antibodies against Yersinia enterocolitica by enzyme-linked immunosorbent assay: persistence of serum antibodies during disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Measurement of immunoglobulin M (IgM), IgG, and IgA antibodies against Yersinia enterocolitica by enzyme-linked immunosorbent assay: persistence of serum antibodies during disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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