There are two major types of agent available to suppress disease activity: calcitonin, and the bisphosphonates (formerly called diphosphonates). Other agents, including fluoride, mithramycin, actinomycin-D, glucocorticoids, colchicine, glucagon and inosiplex, have also been investigated, but are either ineffective, toxic or both
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Cantrill et al. (1990) studied this question.
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