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July 1, 1989Muscle & Nerve

Accumulation of collagen and altered fiber‐type ratios as indicators of abnormal muscle gene expression in the mdx dystrophic mouse

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Authors

PMPhillip MarshallTufts University PWPamela WilliamsUniversity of Michigan GGGeoffrey GoldspinkUniversity College London

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Implication

Early fiber-type shifts in mdx mice warrant model-interpretation caution; leaves open human DMD translation and therapeutic relevance.

Key Points

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Cite This Study

Marshall et al. (1989) studied this question.

synapsesocial.com/papers/6a87c5183bdf89560ead2e3e https://doi.org/10.1002/mus.880120703

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Characterisation of Progressive Skeletal Muscle Fibrosis in the Mdx Mouse Model of Duchenne Muscular Dystrophy: An In Vivo and In Vitro Study2022 · 33 citations
2Lifespan Analysis of Dystrophic mdx Fast-Twitch Muscle Morphology and Its Impact on Contractile Function2021 · 16 citations
3Lifespan analysis of dystrophic mdx fast-twitch muscle morphology and its impact on contractile function2021 · 3 citations
4Comparative proteomic profiling of soleus, extensor digitorum longus, flexor digitorum brevis and interosseus muscles from the mdx mouse model of Duchenne muscular dystrophy2013 · 41 citations
5Dystrophin-negative slow-twitch soleus muscles are not susceptible to eccentric contraction induced injury over the lifespan of the mdx mouse2021 · 25 citations