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The failure of previous studies to indicate clear differences in the relative seizure control and side effects of the major antiepileptic drugs has resulted from insufficient clinical trials or limitations in earlier studies. The principles for designing studies of the efficacy and toxicity of major antiepileptic drugs are outlined. These standards apply to the evaluation of new and old antiepileptic drugs used for all types of seizures in diverse populations.
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Escueta et al. (1983) studied this question.
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