What question did this study set out to answer?

To propose a biophysical theory of muscle contraction wherein tension is generated by myosin-induced structural alterations and lengthening of actin filaments.

January 1, 1992Proceedings of the National Academy of SciencesOpen Access

Actin as the generator of tension during muscle contraction.

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Authors

CSClarence E. SchuttPrinceton University ULUno LindbergUppsala University

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Implication

Does not support immediate changes in heart failure therapies; extends theoretical models of sarcomere function for further investigation.

Key Points

To propose a biophysical theory of muscle contraction wherein tension is generated by myosin-induced structural alterations and lengthening of actin filaments.
Formulated a structural model of chemical-to-mechanical energy transduction based on actin ribbon transitions.
Analyzed the geometric commensurability between the actin ribbon subunit repeat and the myosin lattice repeat.
Helical actin filaments untwist into ribbons with a 35.7 Å subunit repeat, creating an integral match with the 429 Å myosin thick filament lattice repeat.
Lattice commensurability between actin ribbons and myosin provides a coordinated sequence for chemical-mechanical energy transduction.
Identified a mechanical role for tropomyosin in propagating the tension generated during actomyosin interactions.

Cite This Study

Schutt et al. (1992) studied this question.

synapsesocial.com/papers/6a87c62902f504243ce96054 https://doi.org/10.1073/pnas.89.1.319

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Implication

Does not support immediate changes in heart failure therapies; extends theoretical models of sarcomere function for further investigation.

Actin as the generator of tension during muscle contraction.

Discussion

Member takes

Implication

Key Points

Cite This Study

Actin as the generator of tension during muscle contraction.

Discussion

Member takes

Implication

Key Points

Cite This Study

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