Why the study?
Do nitrates improve clinical outcomes in patients with acute heart failure?
Do nitrates improve clinical outcomes in patients with acute heart failure?
Nitrates appear to be underused in acute heart failure despite having favorable effects on symptoms, blood pressure, intubation rates, and mortality when appropriately dosed.
Nitrates may warrant consideration in acute heart failure; leaves open confirmation of outcome benefits in randomized trials.
The purpose of this article is to review the clinical efficacy and safety of nitrates in acute heart failure (AHF) by examining various trials on nitrates in AHF. Management of AHF can be challenging due to the lack of objective clinical evidence guiding optimal management. There have been many articles suggesting that, despite a benefit, nitrates are underused in clinical practice. Nitrates, when appropriately dosed, have a favourable effect on symptoms, blood pressure, intubation rates, mortality and other parameters.
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Alzahri et al. (2016) studied this question.
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