January 8, 2017Antiviral ResearchOpen Access

Biological or pharmacological activation of protein kinase C alpha constrains hepatitis E virus replication

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Why the study?

Does activation of PKCα inhibit HEV replication in a cell culture model?

Structured PICO

Does activation of PKCα inhibit HEV replication in a cell culture model?

Population

Cell culture model, a subgenomic HEV replicon containing luciferase reporter

Intervention

Pharmacological kinase inhibitors, specific inhibitor and shRNA-mediated knockdown of PKCα, over-expression of activated form of PKCα, or treatment with its pharmacological activator

Outcome

HEV replicationsurrogate

Activation of PKCα restricts HEV replication, providing a potential new target for antiviral drug development.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

PKCα activation may restrict HEV in cell models; leaves open in vivo efficacy and clinical translation.

Cite This Study

Wang et al. (2017) studied this question.

synapsesocial.com/papers/6a87c8d26e1dca10b7bb5a3f https://doi.org/10.1016/j.antiviral.2017.01.005

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