Why the study?
Does candesartan alter arterial pressure and renal hemodynamics in response to angiotensin II in normal anesthetized rats?
Population
Normal anesthetized rats
Comparison
Candesartan (doses of 1, 0.1, and 0.01 mg/kg) vs Baseline/control responses to bolus angiotensin…
Design
Preclinical
Authors
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Does not inform clinical dosing; leaves open whether low-dose renal effects translate to human hypertension or HF.
Does candesartan alter arterial pressure and renal hemodynamics in response to angiotensin II in normal anesthetized rats?
Candesartan is a potent noncompetitive blocker of ANG II pressor and renal vasoconstrictor effects, with lower doses revealing direct renal vasodilator and natriuretic effects.
Červenka et al. (1998) studied this question.
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