Why the study?
Does intestinal trypsin cleave VP1 and modify antigenic site 1 of type 2 polioviruses, and how does this affect neutralization by vaccine-induced sera?
Population
22 independent type 2 poliovirus isolates, and sera from persons immunized solely with inactivated…
Comparison
Exposure to human intestinal fluid and purified… vs Intact type 2 polioviruses
Design
Preclinical
Authors
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Intestinal trypsin cleavage may reduce neutralization of type 2 poliovirus by IPV sera; leaves open site 1's relative role in human immunity.
Does intestinal trypsin cleave VP1 and modify antigenic site 1 of type 2 polioviruses, and how does this affect neutralization by vaccine-induced sera?
While antigenic site 1 of type 2 poliovirus is immunogenic in humans when IPV is used, its relative role in human immunity appears less critical than in type 3 polioviruses.
Roivainen et al. (1988) studied this question.
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