Oligonucleotide mapping revealed that the 1982 polio outbreak in South Africa was caused by multiple wild-type strains rather than a vaccine-derived or single wild-type strain.
Highlights diverse wild-type polio strains in historical outbreaks; leaves open implications for modern genomic surveillance.
An outbreak of paralytic poliomyelitis, due to polio type 1 virus, occurred in the Gazankulu region of the Transvaal in the Republic of South Africa in 1982. Thirty-four different isolates from this epidemic were characterized by oligonucleotide mapping. None of the isolates were shown to be vaccine related. Results suggest the existence of a number of apparently different wild-type viruses present in the area. The introduction of a single wild-type strain could not be clearly demonstrated. These findings have important implications for the management and control of future outbreaks.
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Tsilimigras et al. (1989) studied this question.
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