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June 25, 2010World Journal of Surgery

Preincisional Versus Postincisional Administration of Parecoxib in Colorectal Surgery: Effect on Postoperative Pain Control and Cytokine Response. A Randomized Clinical Trial

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Authors

APAgeliki PandaziEKE. KapotaPMParaskevi Matsota

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Pandazi et al. (2010) studied this question.

synapsesocial.com/papers/6a87ccfb6841b83273ad2c9ahttps://doi.org/10.1007/s00268-010-0696-9
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intravenous Parecoxib Rapidly Leads to COX-2 Inhibitory Concentration of Valdecoxib in the Central Nervous System2007 · 30 citations
  2. 2Presurgical intravenous parecoxib sodium and follow‐up oral valdecoxib for pain management after laparoscopic cholecystectomy surgery reduces opioid requirements and opioid‐related adverse effects2004 · 98 citations
  3. 3Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1β, Interleukin-6, and Tumor Necrosis Factor-α in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord2008 · 1,163 citations
  4. 4Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states1995 · 660 citations