Population
Native poliovirus (160S or N particle)
Design
Preclinical
Authors
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May guide capsid-stabilizing antivirals; leaves open generalization to human enteroviral disease.
The poliovirus receptor acts as a catalyst for viral uncoating by lowering activation energy, and capsid-binding drugs inhibit this process through both enthalpic and entropic effects.
Tsang et al. (2001) studied this question.
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