June 15, 2001Journal of VirologyOpen Access

Inhibition of L-Deleted Foot-and-Mouth Disease Virus Replication by Alpha/Beta Interferon Involves Double-Stranded RNA-Dependent Protein Kinase

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Structured PICO

Population

Porcine and bovine cells, and mouse embryonic fibroblast cells derived from RNase L(-/-) or PKR(-/-) or both knockout mice infected with foot-and-mouth disease virus (FMDV)

Intervention

Escherichia coli-expressed porcine and bovine IFN-alpha or -beta; 2-aminopurine (PKR inhibitor)

Comparator

Untreated infected cells

Outcome

FMDV replication/yieldsurrogate

Alpha/beta interferon inhibits FMDV replication via a mechanism involving double-stranded RNA-dependent protein kinase (PKR).

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports PKR as mediator of interferon inhibition of FMDV; extends mechanistic insight but leaves open in vivo relevance.

Cite This Study

Chinsangaram et al. (2001) studied this question.

synapsesocial.com/papers/6a87ce754f54442d18262f12 https://doi.org/10.1128/jvi.75.12.5498-5503.2001

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Inhibition of L-Deleted Foot-and-Mouth Disease Virus Replication by Alpha/Beta Interferon Involves Double-Stranded RNA-Dependent Protein Kinase

Structured PICO

Discussion

Implication

Cite This Study

Inhibition of L-Deleted Foot-and-Mouth Disease Virus Replication by Alpha/Beta Interferon Involves Double-Stranded RNA-Dependent Protein Kinase

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider